Published Desmoid Tumor Research

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Date TITLE SUMMARY AUTHORS INSTITUTION

new2c Sep 2014

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A giant mesenteric desmoid tumor revealed by acute pulmonary embolism due to compression of the inferior vena cava. We report the case of a 69-year-old man who presented to our hospital with an acute pulmonary embolism. The patient had a past history of colic surgery for a polyp with a high-grade dysplasia. Pulmonary angiography showed partial occlusion of the right superior lobe artery and partial occlusion of the middle lobe artery. The patient was given thrombolytic therapy. Abdominal computerized tomography revealed a mesenterial giant mass with compression of the inferior vena cava (IVC). A biopsy of the mass, confirming aggressive fibromatosis. This report underlines the potential of imaging investigations of abdomen and vena cava if pulmonary embolism is suspected, especially when there is no evidence of peripheral venous thrombosis or other predisposing factors. Christian Lechner,Elisa Palladino,Joseph Nsenda,Renaud Siboni Department of General and Digestive Surgery, Chalons en Champagne Hopsital, Chalons en Champagne, France.,Department of General and Digestive Surgery, Chalons en Champagne Hospital, Chalons en Champagne, France.

new2c Aug 2014

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Impact of KIT exon 10 M541L allelic variant on the response to imatinib in aggressive fibromatosis: analysis of the desminib series by competitive allele specific Taqman PCR technology. The phase II "Desminib trial" included 40 patients with AF to evaluate the toxicity and efficacy of imatinib resulting in a 65% tumor control rate at 1 year. We investigated a potential predictive value of KIT exon 10 M541L variant (KITL541) on this prospective series. Armelle Dufresne,David Pérol,Héloïse Philippon,Jean Yves Blay,Laurent Alberti,Mehdi Brahmi,Sarah Kabani Cancer Research Center of Lyon, INSERM UMR 1052, CNRS UMR 5286, Centre Leon Berard, 28 rue Laënnec, Lyon, France. a.dufresne@hotmail.com.

new2c Aug 2014

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Clinical Characteristics and Adequate Treatment of Familial Adenomatous Polyposis Combined with Desmoid Tumors. The objective of this study was to examine the clincopathologic characteristics and outcomes of familial adenomatous polyposis (FAP) patients with and without desmoid tumors (DTs), including the risk factors for progression of FAP-related Dts. In univariate analysis, DT diagnosis before or simultaneously with FAP diagnosis (DTs unrelated to surgical trauma) was a significant risk factor for tumor progression at final follow-up. Chan Wook Kim,Jin Cheon Kim,Won Beom Jung

new2c Aug 2014

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Intra-abdominal Desmoid Tumor after Resection for Gastrointestinal Stromal Tumor of the Small Intestine: Case Report. The case of a 56-year-old male with a desmoid tumor 1 year after surgical removal of a gastrointestinal stromal tumor near the ligament of Treitz is described. Although he received adjuvant therapy of imatinib mesylate for 1 year after the surgery, a small nodule was found 1 year and 3 months after the surgery. The nodule was considered to be a recurrent tumor of gastrointestinal stromal tumor, and a wedge resection of the duodenum including the tumor was done. Histopathological examination by immunohistochemical staining revealed that it was a desmoid tumor. It would be useful to be aware of the possibility of desmoid tumor after removal of gastrointestinal stromal tumor. To accumulate further information on these rare diseases, a central database that includes rare diseases will be necessary. Hirotoshi Kobayashi,Kenichi Sugihara Center for Minimally Invasive Surgery, Division of Colorectal Surgery, Tokyo Medical and Dental University, Tokyo h-kobayashi.srg2@tmd.ac.jp.,Department of Surgical Oncology, Tokyo Medical and Dental University, Tokyo, Japan.

new2c Aug 2014

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Multimodality imaging of common and uncommon peritoneal diseases: a review for radiologists. Peritoneal disease can be caused by a wide spectrum of pathologies. This article begins with an overview of peritoneal embryology and anatomy followed by a detailed description of the multimodality imaging appearance of peritoneal diseases. The uncommon diseases which cause peritoneal disease include desmoid fibromatosis, desmoplastic small round cell tumor, malignant mesothelioma, well-differentiated mesothelioma, multicystic mesothelioma, papillary serous carcinoma, leiomyomatosis, extramedullary hematopoiesis, inflammatory pseudotumor and amyloidosis. This manuscript will help the radiologist become familiar with the different peritoneal spaces, pathways of spread, multimodality imaging appearance and differential diagnoses of peritoneal diseases in order to report the essential information for surgeons and oncologists to plan treatment. Aparna Balachandran,Christine O Menias,Madhavi Patnana,Ott Le,Priya R Bhosale,Rafael A Vicens,Tara L Sagebiel Department of Diagnostic Radiology, Unit 1473, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030-4009, USA, rafomd@gmail.com.

new2c Aug 2014

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Pregnancy does not increase the local recurrence rate after surgical resection of desmoid-type fibromatosis. Pregnancy has been reported as a risk factor for promoting growth and progression of desmoid-type fibromatosis because of the presumed role of estrogens in stimulating desmoid growth. Recurrence-free survival rates among women recently pregnant before or pregnant after resection of desmoid tumor and nulliparous women or those with a remote history of pregnancy are comparable after adjusting for patient age, anatomic location, and completeness of surgical resection. Subsequent pregnancy should not be discouraged for reproductive-aged women after resection of desmoid-type fibromatosis. Justin M M Cates Department of Pathology, Vanderbilt University Medical Center, Medical Center North, CC-3322, 1161 21st Ave. South, Nashville, TN, 37232, USA, justin.m.cates@vanderbilt.edu.

new2c Aug 2014

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The desmoid tumour: Local control after surgical treatment. Patients referred to the soft tissue tumour group at Helsinki University Central Hospital (HUCH) for a desmoid tumour (primary or recurred) during 1987-2007 and receiving surgical treatment with or without adjuvant treatment were included in this retrospective review. All locations and also patients with a FAP-associated tumour were included. Extra-abdominal location showed lower local control despite the fact that 27% of patients also received radiation therapy. In this review, the occurrence (14%) of concurrent neoplasms was higher than expected with unusual tumour types noted including two GISTs. In those patients in whom surgical treatment is chosen, adjuvant radiation therapy should also be considered in order to decrease morbidity from aggressive surgery aiming at R0 resection. Further studies are suggested to illuminate the biological association between the desmoid tumour and other neoplasms. Erkki J Tukiainen,Hanna R Ihalainen,Mika M Sampo,Tom O Böhling,Virve Koljonen Department of Plastic Surgery, Helsinki University Central Hospital , Helsinki , Finland.

new2c Aug 2014
Revised Aug 2014

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Treatment and follow-up strategies in desmoid tumours: a practice guideline. We set out to determine the optimal treatment options-surgery, radiation therapy (rt), systemic therapy, or any combinations thereof-for patients with desmoid tumours once the decision to undergo active treatment has been made (that is, monitoring and observation have been determined to be inadequate).provide clinical-expert consensus opinions on follow-up strategies in patients with desmoid tumours after primary interventional management. Surgery with or without rt can be a reasonable treatment option for patients with desmoid tumours whose surgical morbidity is deemed to be low.The decision about whether rt should be offered in conjunction with surgery should be made by clinicians and patients after weighing the potential benefit of improved local control against the potential harms and toxicity associated with rt. Depending on individual patient preferences, systemic therapy alone or rt alone might also be reasonable treatment options, regardless of whether the desmoid tumours are deemed to be resectable. A A Gupta,J Werier,M Ghert,R A Kandel,S Verma,T Corbett,X Yao Cancer Care Ontario's Program in Evidence-Based Care, Department of Oncology, McMaster University, Hamilton, ON.,Department of Medical Oncology, The Ottawa Hospital Regional Cancer Centre, Ottawa, ON.,Department of Orthopaedic Surgery, The Ottawa Hospital Regional Cancer Centre, Ottawa, ON.,Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON.,Department of Radiation Oncology, Juravinski Cancer Centre, Hamilton, ON.,Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON.,Division of Orthopaedic Surgery, Juravinski Cancer Centre, Hamilton, ON.

new2c Aug 2014
Revised Aug 2014

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A systematic review of active treatment options in patients with desmoid tumours. We conducted a systematic review to determine the optimal treatment options in patients with desmoid tumours who have declined observational management. Significant toxicities were reported for all treatment modalities, including surgical morbidity, and rt- and chemotherapy-related toxicities. In patients who have declined observational management, the local control rate was higher with surgery plus rt than with surgery alone. However, the additional rt-related complications should be considered in treatment decision-making. Surgery, rt, and systemic therapy are all reasonable treatment options for patients with desmoid tumours. A A Gupta,J Werier,M Ghert,R A Kandel,S Verma,T Corbett,X Yao Cancer Care Ontario's Program in Evidence-Based Care, Department of Oncology, McMaster University, Hamilton, ON.,Department of Medical Oncology, The Ottawa Hospital Regional Cancer Centre, Ottawa, ON.,Department of Orthopaedic Surgery, The Ottawa Hospital Regional Cancer Centre, Ottawa, ON.,Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON.,Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON.,Division of Orthopaedic Surgery, Juravinski.,Division of Radiation Oncology, Juravinski Cancer Centre, Hamilton, ON.

new2c Aug 2014

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Sonographic appearances of desmoid tumors. The medical records of 16 patients (9 female and 7 male; age range, 5-66 years) with 24 lesions that had a histologic diagnosis of desmoid tumors were reviewed at our institution. Six cases were extra-abdominal, 4 intra-abdominal, and 6 in the abdominal wall. Sonography can show a desmoid tumor's site, size, contour, margin, echogenicity, homogeneity, vascularity, and resistive index value in detail. Hengtao Qi,Jianbo Teng,Li Lou,Yongguang Ban Department of Ultrasound, Shandong Medical Imaging Research Institute, Shandong University, Jinan, China.,Department of Ultrasound, Shandong Medical Imaging Research Institute, Shandong University, Jinan, China. jbteng2013@163.com.

new2c Jul 2014

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Desmoid-type fibromatosis-associated Gardner fibromas: prevalence and impact on local recurrence. Although Gardner fibroma is a precursor lesion of desmoid tumor, the prevalence and prognostic importance of Gardner fibroma associated with desmoid tumors has not been systematically studied in adults. Clinicopathologic features of Gardner fibroma-associated desmoid-type fibromatosis were compared to desmoid tumors without associated Gardner fibroma. Desmoid tumors arising in high risk anatomic sites (extremities or deep soft tissues of the back and chest wall) were more often associated with Gardner fibroma than tumors at other sites. Median recurrence-free survival for patients with Gardner fibroma-associated desmoid-type fibromatosis was 3.2 years, whereas median survival for patients without associated Gardner fibroma was >25 years (hazard ratio 2.8; P = 0.001). Although the presence of Gardner fibroma had no impact on the recurrence rate of desmoid tumors arising at high risk anatomic sites, associated Gardner fibroma increased the risk of recurrence 4-fold for desmoid tumors at low risk anatomic sites. Associated Gardner fibroma is under-recognized in desmoid-type fibromatosis and increases the risk of local recurrence for a subgroup of patients. Cheryl M Coffin,Duveen Sturgeon,Justin M M Cates,Thomas P Stricker Department of Pathology, Vanderbilt University Medical Center, 1161 21st Ave. South, Nashville, TN 37232, USA.,Department of Pathology, Vanderbilt University Medical Center, 1161 21st Ave. South, Nashville, TN 37232, USA. Electronic address: justin.m.cates@vanderbilt.edu.,Division of General Surgery, Vanderbilt University Medical Center, 1161 21st Ave. South, Nashville, TN 37232, USA.

new2c Jul 2014

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Desmoid tumors of the upper extremity. Recurrence after surgical excision of a desmoid tumor in the upper extremity is common, especially in younger patients. Adjuvant radiation therapy tended to increase time to recurrence but not rate of recurrence. Matthew T Houdek,Peter S Rose,Sanjeev Kakar Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN.,Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN. Electronic address: kakar.sanjeev@mayo.edu.

new2c Jul 2014

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P-030 cryoablation in the cervical spine. Patient example: 57 year old female with a newly diagnosed desmoid which extended from C3-T2. Current standard of care would be surgical resection followed by radiation therapy. Given the size of the lesion it was felt she would need cervical stabilization and possibly a latissimus flap. The patient was referred to our service to discuss less invasive options. Myelographic dye was placed for visualization, the spinal cord was hydrodissected away from the posterior elements using and epidural catheter, and neural monitoring was used and demonstrated no changes through the case. A total of 10 probes (Galil) were used and the lesion was cryoablated for 7 min, passively thawed for 10 min and reablated for 15 min. There was no post procedure weakness, and she was discharged postprocedure day 1, back to work on day 5. J Morris,M Callstrom Mayo Clinic, Rochester, MN, USA.

new2c Jul 2014
Revised Jul 2014

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Huge facial desmoid tumors with neck extension: a case report. The patient was a seven-year old boy with a large mandibular mass growing over a period of six months. His CT-scan showed a large mass, 13 cm in diameter in the cheek area extending to the neck and trachea. Biopsy was compatible with desmoid fibromatosis. Despite rarity desmoid tumors should be kept in mind of an otorhinolaryngologist as a differential diagnosis in children with head and neck mass. Ali Ghazipour,Bassel Bradd,Fariborz Saleheh,Shervin Ghavami Lahiji Department of Otorhinolaryngology, Damascus University of Medical Sciences, Damascus, Syria.,Department of Otorhinolaryngology, Jondishapour University of Medical Sciences, Ahwaz, Iran.,Department Oral and maxillofacial surgery, Damascus University of Medical Sciences, Damascus, Syria.

new2c Jun 2014
Revised Jul 2014

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Intra-abdominal desmoid tumor after liver transplantation: A case report. We are reporting the first documented case of an abdominal desmoid tumor presenting primarily after liver transplantation. This tumor, well described in the literature as occurring both in conjunction with familial adenomatous polyposis as well as in the post-surgical patient, has never been noted after solid organ transplantation and was therefore not included in our differential upon presentation. Our case and the literature show the risk of this tumor presenting in the post-transplantation patient and the need for a high index of suspicion in patients who present with a complex mass after transplantation to prevent progression of the disease beyond a resectable lesion. Edie Y Chan,Shannon Zielsdorf,Sheila Eswaran,Shriram Jakate,Vidya A Fleetwood Vidya A Fleetwood, Shannon Zielsdorf, Edie Y Chan, Department of General Surgery, Division of Transplantation Surgery, Rush University Medical Center, Chicago, IL 60612, United States.

new2c Jan 2014
Revised Jul 2014

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Desmoid fibromatosis of submandibular region. We report a case of desmoid tumor in the submandibular region in a 32-year-old male who presented with right submandibular swelling postextraction of right lower wisdom tooth. Excision biopsy was carried out initially following inconclusive fine needle aspiration and discussion at multidisciplinary meeting. The tumor recurred 4 months following initial excisional biopsy necessitating a more radical secondary approach involving segmental mandibulectomy. Intraoperatively we also noted that the tumor was originating from the site of previous wisdom tooth extraction, raising the question of surgical trauma as precursor of desmoid tumor. We achieved a negative resection margin and a complete remission for 24 months. Nirmalatiban Parthiban,Rohana Ali,Tadgh O'Dwyer Department of Otorhinolaryngology, Head and Neck Surgery, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland.,Department of Surgery, Perdana University- Royal College of Surgeons Ireland, Malaysia. Block B and D1, MAEPS building, MARDI Complex, Jalan MAEPS Perdana, 43400 Serdang, Selangor, Malaysia ; Department of Otorhinolaryngology, Head and Neck Surgery, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland.,Department of Surgery, Perdana University- Royal College of Surgeons Ireland, Malaysia. Block B and D1, MAEPS building, MARDI Complex, Jalan MAEPS Perdana, 43400 Serdang, Selangor, Malaysia.

Jun 2014

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Gene expression identifies heterogeneity of metastatic behavior among high-grade non-translocation associated soft tissue sarcomas. The biologic heterogeneity of soft tissue sarcomas (STS), even within histological subtypes, complicates treatment. In earlier studies, gene expression patterns that distinguish two subsets of clear cell renal carcinoma (RCC), serous ovarian carcinoma (OVCA), and aggressive fibromatosis (AF) were used to separate 73 STS into two or four groups with different probabilities of developing metastatic disease (PrMet). This study was designed to confirm our earlier observations in a larger independent data set. Amy Pn Skubitz,Frédéric Chibon,Jean-Michel Coindre,Keith M Skubitz,Pauline Lagarde,Wayne W Xu,Xianghua Luo Department of Medicine, University Hospital, Minneapolis, MN, USA. skubi001@umn.edu.

Jun 2014

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[Very late effects of radiotherapy -  limiting factor of current radiotherapy techniques]. Very late effects of radiotherapy occur within decades after the initial exposure. Their development is induced by low doses of ionizing radiation (from 4 Gy per radiation series) and their clinical manifestations are difficult to distinguish from other independent diseases diagnosed in individuals not formerly treated with radiation. A long time period from the exposure confounds any causal relationships between radiation and adverse events. Still, these side effects not only reduce the patients quality of life but also lead to an early morbidity and mortality, hence generating significant costs in health care and social systems. This article summarizes findings about the most common very late consequences of radiotherapy, which include cardiotoxicity, CNS toxicity, pneumotoxicity, renal toxicity and secondary malignancies. This issue is crucial in the group of children cancer patients, malignant lymphomas, testicular tumors and CNS tumors. Generally, the risk of very late effects of radiotherapy (RT) should be considered in all patients irradiated at a relatively early age with a high chance of long/ term survival. The risk of very late effects of RT is also one of the key limiting factors in the use of RT in the treatment of paients with benign lesions with longterm survival expectation, e. g. in paients with glomus tumors, neurofibromas, desmoid tumors or hemangiomas or other benign lesions (arterio venous malformations). Currently, the only known prevention of these very late adverse effects is to minimize the dose to critical structures to the lowest achievable level B Ondrová,J Kubeš,K Dědečková,P Vítek

Apr 2014
Revised Jun 2014

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Multiple desmoid tumors in a patient with Gardner's syndrome - Report of a case. We report a case of a 32 years-old female patient with familial adenomatous polyposis (FAP), who was already submitted to total colectomy and developed multiple DT, located in the abdominal wall and in the left breast. The patient underwent several surgical procedures, with a multidisciplinary team of surgeons. After partial necrosis of the adipose-cutaneous flap in the abdomen that required a new skin graft, she had a satisfactory outcome with complete healing of the surgical incisions. Cesar Cabello,Cláudio Saddy Rodrigues Coy,Ivan Toro,João José Fagundes,Lílian Vital Pinheiro,Marc Ward,Marcelo Michellino,Maria de Lourdes Setsuko Ayrizono,Paulo Henrique Fachina,Raquel Franco Leal Coloproctology Unit, Department of Surgery, University of Campinas, UNICAMP, Campinas, Sao Paulo, Brazil.,Coloproctology Unit, Department of Surgery, University of Campinas, UNICAMP, Campinas, Sao Paulo, Brazil. Electronic address: rafranco.unicamp@gmail.com.,Mastology Unit, Department of Gynecology, University of Campinas, UNICAMP, Campinas, Sao Paulo, Brazil.,Plastic Surgery Unit, Department of Surgery, University of Campinas, UNICAMP, Campinas, Sao Paulo, Brazil.,Toracic Surgery Unit, Department of Surgery, University of Campinas, UNICAMP, Campinas, Sao Paulo, Brazil.,University of Chicago Medical Center, Chicago, IL, United States.

May 2014
Revised Jun 2014

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Clinical response to sunitinib as a multitargeted tyrosine-kinase inhibitor (TKI) in solid cancers: a review of clinical trials. Sunitinib is an oral multitargeted tyrosine-kinase inhibitor that blocks activation through the stem cell-factor receptor (Kit) and platelet-derived growth-factor receptor. Sunitinib has shown potent antitumor activity against several solid tumors, including renal cell carcinoma, gastrointestinal stromal tumors, and neuroendocrine tumors in several Phase II/III trials. Recently, sunitinib has been used to treat other solid cancers, such as lung cancer, pancreatic cancer, chondrosarcoma, esophageal cancer, bladder cancer, glioma, and aggressive fibromatosis, and also showed potential efficacy in progression-free survival and overall survival. In this review, we examine the efficacy of sunitinib as a molecular-targeted therapy in patients with different types of solid cancers. Lian Zhang,Siyu Chen,Sungkyoung Kim,Wei Tian,Wenping Ding Department of Oncology, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

 May 2014

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Prognostic factors for desmoid tumor: a surgical series of 233 patients at a single institution. We sought to determine the rates of recurrence after surgery for desmoid tumors and analyze factors predictive of recurrence-free survival (RFS). From February 1976 to October 2011, 233 consecutive patients with desmoid tumors who underwent macroscopically complete resection were included in this study. Clinicopathologic and treatment characteristics were evaluated to determine predictors of recurrence. Regardless of primary or recurrent disease, surgical resection remains central to the management of patients with desmoid tumors. However, there are clearly different prognostic subgroups that could benefit from different therapeutic strategies, and a wait-and-see policy is a possible option for a subset of patients. Hai-Tao Zhou,Hui-Rong Hou,Jian-Wei Liang,Jun-Jie Hu,Wei-Gen Zeng,Xing-Mao Zhang,Zheng Wang,Zhi-Xiang Zhou Department of Colorectal Surgery, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, 17 Panjiayuan Nanli, Chaoyang District, 100021, Beijing, China.

 May 2014

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CTNNB1 S45F Mutation Predicts Poor Efficacy of Meloxicam Treatment for Desmoid Tumors: A Pilot Study. This study aimed to determine the significance of CTNNB1 (β-catenin) mutations in predicting the treatment outcome in patients with desmoid tumors treated with meloxicam, a cyclooxygenase-2 (COX-2) selective inhibitor. Between 2003 and 2012, consecutive thirty-three patients with extra-peritoneal sporadic desmoid tumors were prospectively treated with meloxicam as the initial systemic medical therapy. The correlation between the efficacy of meloxicam treatment and status of CTNNB1 mutations was analyzed. The CTNNB1 mutation status was of significant prognostic value for meloxicam treatment in patients with sporadic desmoid tumors. Eiji Kozawa,Hiroshi Urakawa,Kunihiro Ikuta,Naohisa Futamura,Naoki Ishiguro,Shunsuke Hamada,Yoshihiro Nishida Department of Orthopaedic Surgery, Nagoya University Graduate School and School of Medicine, Nagoya, Japan.

 May 2014

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Desmoid tumor requiring differentiation from port-site relapse after surgery for lung cancer. Thoracoscopic left lower lobectomy with lymph node dissection for lung cancer was performed in a 76-year-old man. Sixteen months after surgery, CT revealed a pleural tumor measuring 38 mm at the surgical port wound. Thoracoscopic tumorectomy was conducted. The pathological diagnosis was desmoid tumor. As the margins of the resected specimen were positive, radiotherapy was performed. During the 16-month follow-up period, there has been no relapse. Pleural desmoid tumors must be differentiated from port-site relapse. Hiroshige Nakamura,Ken Miwa,Kunio Araki,Makoto Wakahara,Shinji Fujioka,Yasuaki Kubouchi,Yuji Taniguchi,Yuzo Takagi Division of General Thoracic Surgery, Tottori University Hospital, Yonago, Japan.

May 2014

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Value of Tumor Vessel Sign in Isolated Circumscribed Hypervascular Abdominopelvic Mesenchymal Tumors on Multidetector Computed Tomography. The objective was to determine the usefulness of the tumor vessel sign for differentiating the groups of circumscribed hypervascular abdominopelvic mesenchymal tumors. We enrolled a total of 4 groups such as patients with gastrointestinal stromal tumor (GIST) (26 patients), those with paraganglioma (9 patients), those with primary sarcomas (13 patients, excluding those with liposarcoma), and those with desmoid tumor (6 patients). The reviewers evaluated the presence of tumor vessels capable of directly tracing from the tumor margin to the named vessels. Twenty-five of 26 GIST cases, all of the paragangliomas, all of the primary sarcomas, and all of the desmoid tumors showed a positive sign. The presence of the sign is considered to be helpful for differentiating the 4 groups of tumors. Jae Young Kim,Jeong Gu Nam,Jong Hwa Lee,Seong Hoon Choi,Yoong Ki Jeong,Young Woo Seo From the Department of Radiology, University of Ulsan College of Medicine, Ulsan University Hospital, Jeonha-dong, Dong-gu, Ulsan, Republic of Korea.

May 2014

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Intra-abdominal desmoid tumor mimicking gastric cancer recurrence: a case report. We report a case of an intra-abdominal desmoid tumor mimicking the recurrence of gastric cancer. A 57-year-old male had undergone distal gastrectomy for advanced gastric cancer. In patients with history of surgery for intra-abdominal malignancies, it may be difficult to distinguish the recurrence of malignancy from desmoid tumors but the possibility of desmoid tumors must be considered in the differential diagnosis. Akihiko Okamura,Aya Sasaki,Hirofumi Kawakubo,Hiroya Takeuchi,Kazumasa Fukuda,Norihito Wada,Rieko Nakamura,Shuhei Mayanagi,Tai Omori,Tsunehiro Takahashi,Yoshiro Saikawa,Yuko Kitagawa Department of Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. tsunehiro-t@a8.keio.jp.

Apr 2014

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Radiotherapy is effective for desmoid tumors (aggressive fibromatosis) - long-term results of a German multicenter study. We addressed the impact of radiation therapy (RT) in the management of aggressive fibromatosis. A large literature review was performed, and the data was compared with the results of a multicenter study of the German Cooperative Group on Radiotherapy for Benign Diseases (GCG-BD). Given the large number of patients, these data show that RT is highly effective in the treatment of desmoid tumors. RT is an attractive alternative to mutilating surgery. Frank Bruns,Hans Theodor Eich,Jan Kriz,Jürgen Heide,M Heinrich Seegenschmiedt,Oliver Micke,Uwe Haverkamp Klinik und Poliklinik für Strahlentherapie - Radioonkologie, Universitätsklinikum Münster, Münster, Germany.

 Apr 2014

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An unusual case of familial adenomatous polyposis with very early symptom occurrence. We report the clinical case of a patient who showed an "accelerated" form of polyposis, with development of major lesions within the first decade of life. The patient belongs to a familial adenomatous polyposis family-already described in 2001-featured by profuse polyposis at an early age of onset and desmoid tumors in the majority of affected individuals (of both sexes). The family was characterized by an uncommon mutation of the APC gene. In 2010, at age 9, the patient was operated of total colectomy and endorectal pull-through of the small intestine owing to profuse colorectal adenomatosis. New desmoids developed in 2011 and 2012, and required chemotherapy. Further analysis of the APC gene in the proband revealed several polymorphisms. One of these (c.398A>G) had not been previously reported, nor was present in two other affected members of the family. The clinical case, and the practical implications for therapy, are discussed according to the most recent theories of colorectal cancer development. Long-term treatment with Cox-2 inhibitors might represent a good option for this patient. Alberto Merighi,Alfredo Cacciari,Carmela Di Gregorio,Federica Domati,Giulia Magnani,Giuseppina Rossi,Luca Reggiani-Bonetti,Maria Anastasia Bianchini,Maurizio Ponz de Leon,Monica Pedroni Dipartimento di Medicina Diagnostica, Clinica e Sanità Pubblica, Università di Modena e Reggio Emilia, Policlinico, Via del Pozzo 71, 41100, Modena, Italy, deleon@unimore.it.

 Jun 2013
Revised Apr 2014

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Desmoid tumor of the facet joint: a case report. Desmoid tumors are rare at facet joints of the spine. We describe a patient with a desmoid tumor of a lumbar facet joint. Han Ga Wi Nam,Hyung Sik Hwang,Sei-Woong Jeon,Seung-Myung Moon Department of Neurosurgery, Dongtan Sacred Heart Hospital, College of Medicine Hallym University, Hwaseong, Gyeonggi, Republic of Korea.

 Apr 2014

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Idiopathic desmoid-type fibromatosis of the pancreatic head: case report and literature review. Desmoid-type fibromatosis (DTF) is an uncommon nonmetastatic fibrous neoplasm. We herein report a case of DTF of unknown cause involving the pancreatic head. Pylorus-preserving pancreaticoduodenectomy was performed due to the patient's debilitating symptoms and suspected malignancy. The pathological examination revealed massive fibroblastic proliferation arising from the musculoaponeurotic tissues, consistent with a diagnosis of DTF. Radical resection is recommended as first-line treatment for pancreatic DTF. Long-term follow-up studies are required to establish the prognosis of pancreatic DTF. Baoling Tian,Changjun Jia,Chaoliu Dai,Feng Xu,Xianmin Bu,Xinlu Wang

 Apr 2014

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Wait-and-See Policy as a First-Line Management for Extra-Abdominal Desmoid Tumors. The disappointing results of current treatments and the ability of extra-abdominal desmoid tumors to spontaneously stabilize have increasingly drawn interest toward conservative management. The objective of this study was to evaluate a wait-and-see policy as a first-line management for extra-abdominal desmoid tumors. This two-center retrospective study involved fifty-five patients with a histologically proven extra-abdominal desmoid tumor. The primary outcome was the cumulative probability of dropping out from the wait-and-see policy. The wait-and-see policy included aggressive management of symptoms. We conducted a review of the relevant published series in which a watchful-waiting strategy was used. The cumulative probability of dropping out from the wait-and-see policy was 9.6% at the time of the last follow-up. A wait-and-see policy is an effective front-line management for patients with primary or recurrent extra-abdominal desmoid tumor. Axelle Bertrand-Vasseur,David Biau,François Gouin,Frédérique Larousserie,Olivier Barbier,Philippe Anract,Sylvain Briand Department of Orthopaedic Surgery, Begin Military Hospital, 69 avenue de Paris, 94163 Saint Mandé, France. E-mail address: olive.barbier@gmail.com.,Departments of Orthopaedic Surgery (D.B. and P.A.) and Pathology (F.L.), Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, Sorbonne Paris Cité, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France. E-mail address for D. B.,Departments of Orthopaedic Surgery (S.B. and F.G.) and Radiology (A.B.-V.), The University Hospital of Nantes, National Institute of Health and Medical Research, UMR-S 957, 1 Place Alexis Ricordeau, 44093 Nantes, France. E-mail address for S. Briand: sylv.

 Mar 2014

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Aggressive fibromatosis: evaluation of prognostic factors and outcomes of surgical treatment. The aim of this study was to evaluate the results of surgical treatment of aggressive fibromatosis and the effects of prognostic factors on recurrence. Forty patients (24 female, 16 male; average age: 31.2 years) diagnosed with aggressive fibromatosis were evaluated retrospectively. Prognostic factors such as age, gender, localization, admission status, compartment status, surgical margin, tumor size and adjuvant radiotherapy were evaluated. There was no statistically significant relation between prognostic factors and recurrence. Clinical results of the patients receiving adjuvant radiotherapy were more satisfactory. Conclusion: Adjuvant radiotherapy administration appears to be a rational treatment method instead of sacrificing function to achieve wide surgical margins. Burçin Keçeci,Dündar Sabah,Güven Yücetürk,Levent Küçük Department of Orthopedics and Traumatology, Ege University Faculty of Medicine, İzmir, Turkey.,Department of Orthopedics and Traumatology, Ege University Faculty of Medicine, İzmir, Turkey. kucuklevent@yahoo.com.

 Mar 2014
Revised Mar 2014

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Desmoid tumor in puerperium period: a case report. Desmoid tumors (DTs) are rare tumors classified as deep fibromatoses taking origin from fascial or musculoaponeurotic structures. With pregnancy and surgical scars considered in the etiology, most anterior abdominal wall DTs occur in women in their reproductive years, especially during a pregnancy or post-partum. Herein, we present development of DT in a female patient in the post-partum period following cesarean delivery, which manifested itself with a growing mass in anterior abdominal wall. In our case, possibility of hematoma most probably located beneath the fascia was considered initially as a complication of cesarean section based on ultrasonographic examination and location of the lesion, while upon lack of either spontaneous regression with eventual diminish in size or resolve of symptoms within six weeks, further investigation via MRI and tru-cut biopsy revealed the diagnosis of abdominal DT. Radical tumor extirpation with resection of an adequate margin of surrounding normal tissue was applied, and the post-operative period was uneventful. Alihan Gurkan,Aziz Sumer,Ercüment Gurluler,Ibrahim Berber,Ilknur Citil,Nazim Gures,Ozgur Kemik Department of General Surgery, University of Acibadem, International Hospital Organ Transplantation Center, Istanbul, Turkey.,Department of Obstetrics and Gynecology, University of Acibadem, International Hospital, Istanbul, Turkey.

 Sep 2013
Revised Mar 2014

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Intra-Abdominal Desmoid Tumour (DT) with Pelvic Extension-A Case Report. We are reporting here a case of DT that presented as an intra-abdominal mass with pelvic extension in a patient who underwent hysterectomy for fibroid uterus seventeen years ago. A clinical diagnosis of ovarian malignancy was made. Ovarian tumour markers for surface epithelial and germ cell tumours were negative. Imaging studies suggested DT and the same was excised surgically. A histopathological diagnosis of DT was made and confirmed with immunohistochemistry (IHC) markers. DT should always be considered especially in female patients with previous history of surgery. Napa Madhusudhan,Padmini Ramachandran,Sathish Selva Kumar,Uday Kumbhar,Veena G Assistant Professor, Department of Pathology, ESI Medical College and Post Graduate Institute of Medical Science and Research (PGIMSR) , Tamil Nadu, India .,Assistant Professor, Department of Surgery, ESI Medical College and Post Graduate Institute of Medical Science and Research (PGIMSR) , Tamil Nadu, India .,Associate Professor, Department of Surgery, ESI Medical College and Post Graduate Institute of Medical Science and Research (PGIMSR) , K.K. Nagar, Chennai-600078, Tamil Nadu, India .,Senior Resident, Department of Pathology, ESI Medical College and Post Graduate Institute of Medical Science and Research (PGIMSR) , Tamil Nadu, India .

Mar 2014

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Desmoid tumors do not prevent proctectomy following abdominal colectomy and ileorectal anastomosis in patients with familial adenomatous polyposis. Elective proctocolectomy has been recommended for patients at high risk of desmoids based on the possibility that cancer in a retained rectum may be unresectable because of desmoid disease. There are no data to support the reality of this concern. Carol Burke,James M Church,Lisa Laguardia,Margaret O'Malley,Matthew F Kalady,Satish K Warrier,Xhileta Xhaja 1Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio 2Sanford R Weiss, MD, Center for Hereditary Colorectal Neoplasia, Cleveland Clinic Foundation, Cleveland, Ohio 3Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio.

 Feb 2014

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Extra-abdominal desmoid fibromatosis - A sarcoma unit review of practice, long term recurrence rates and survival. Desmoid fibromatosis (DF) carries a significant morbidity and a recognised mortality. Despite this there are currently limited diagnostic or treatment algorithms specific to cases of extra-abdominal DF. Historically surgical excision has formed the cornerstone of treatment. Recently however a paradigm shift has meant many practitioners now adopt a more conservative approach, placing emphasis on active surveillance, function preserving resections, and non-surgical oncologic therapies. C J Richards,C P Esler,N Eastley,R Aujla,R Silk,R U Ashford,T A McCulloch Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Infirmary Square, Leicester LE1 5WW, United Kingdom. Electronic address: cathy.richards@uhl-tr.nhs.uk.,Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Infirmary Square, Leicester LE1 5WW, United Kingdom. Electronic address: neastley@doctors.org.uk.,Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Infirmary Square, Leicester LE1 5WW, United Kingdom. Electronic address: randeep.aujla@hotmail.co.uk.,Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Infirmary Square, Leicester LE1 5WW, United Kingdom; Nottingham City Hospital, Nottingham University Hospitals NHS Trust, Hucknall Road, Nottingham NG5 1PB, United Kingdom. Electronic address: claire.esler@uhl-tr.nhs.uk.,Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Infirmary Square, Leicester LE1 5WW, United Kingdom; Nottingham City Hospital, Nottingham University Hospitals NHS Trust, Hucknall Road, Nottingham NG5 1PB, United Kingdom; Academic Orthopaedics, Trauma & Sports Medicine, University of Nottingham, United Kingdom. Electronic address: robert.ashford@sky.com.,Nottingham City Hospital, Nottingham University Hospitals NHS Trust, Hucknall Road, Nottingham NG5 1PB, United Kingdom. Electronic address: Robert.Silk@nuh.nhs.uk.,Nottingham City Hospital, Nottingham University Hospitals NHS Trust, Hucknall Road, Nottingham NG5 1PB, United Kingdom. Electronic address: Tom.McCulloch@nuh.nhs.uk.

Feb 2014

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Risk of desmoid tumours after open and laparoscopic colectomy in patients with familial adenomatous polyposis. The purpose of this study was to evaluate the impact of prophylactic laparoscopic colectomy on the risk of developing DT in patients with FAP. Patients with classical FAP with defined genotype who underwent either open or laparoscopic colectomy between 1947 and 2011 were included in the study. Laparoscopic surgery decreased the risk of DT after prophylactic colectomy in patients with FAP. D A Kleiman,E M Civelli,G Ballardini,K P Morrissey,L Bertario,M Vitellaro,P Radice,P Sala,S Fortuzzi,S Signoroni Colorectal Surgery Unit, Department of Surgery, Milan, Italy; Department of Surgery, New York Presbyterian Hospital - Weill Cornell Medical College, New York, USA.

Feb 2014

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Aggressive fibromatosis: is PET-CT useful in lesion characterization? We present a case of a 64-year-old man with a hard painless lump in his left calf. The solid and partially hypervascular appearance on ultrasound, the infiltrative appearance, lesion heterogeneity and heterogeneous enhancement pattern on Magnetic Resonance Imaging (MRI) were suspicious for a soft tissue sarcoma. Moreover, PET-CT demonstrated FDG-avidity. Despite these aggressive imaging features, histopathology revealed a benign but locally aggressive desmoid tumour. The radiologist should be aware that PET-CT is not always helpful as an additional tool for differentiation between malignant and benign soft tissue lesions. Intralesional bandlike areas of low signal intensity on all pulse MR sequences and intimate relationship with the muscle fascia are more useful clues to the diagnosis of this soft tissue lesion. F M Vanhoenacker,N S Chew Department of Radiology, AZ Sint-Maarten, Duffel-Mechelen, Belgium.,Department of Radiology, Bradford Royal Infirmary, United Kingdom.

Feb 2014

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Age-based treatment of aggressive fibromatosis in the head and neck region. To review our experience regarding the difference in management and treatment outcomes of aggressive fibromatosis of the head and neck region in children and adults, emphasizing, in particular, the role of conservative surgery in comprehensive treatment strategies. Delin Lei,Guicai Liu,Mingchao Ding,Shufang Ma,Ujjwal Koirala,Weiqi Wang,Xiaoguang Hu Associate Professor, Department of Oral and Maxillofacial Surgery, Fourth Military Medical University School of Stomatology, Xi'an, China.,Professor, Department of Oral and Maxillofacial Surgery, Fourth Military Medical University School of Stomatology, Xi'an, China. Electronic address: huxiaoguang@fmmu.edu.cn.,Professor, Head of Department, Department of Oral and Maxillofacial Surgery, Fourth Military Medical University School of Stomatology, Xi'an, China.,Resident, Department of Oral and Maxillofacial Surgery, Jiamusi University School of Stomatology, Jiamusi, China.,Senior Resident, Department of Oral and Maxillofacial Surgery, Fourth Military Medical University School of Stomatology, Xi'an, China.,Senior Resident, Department of Pediatric Dentistry, Fourth Military Medical University School of Stomatology, Xi-an, China.

Feb 2014

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Aggressive fibromatosis. Aggressive (deep or desmoid-type) fibromatoses are locally infiltrative collagen-forming tumours with potential for recurrence but not metastasis. They exert their clinical effects primarily in relation to location and have variable biological behaviour. In sporadic cases there are somatic mutations in the β-catenin (CTNNB1) gene on 3p21, resulting in immunohistochemically demonstrable overexpression in nuclei. Fibromatosis in patients with familial adenomatous polyposis (FAP) harbours inactivating germline mutations in the desmoid region of the adenomatous polyposis coli (APC) gene on 5q21-q22. The primary management is surgical, though some desmoids cease to grow and can be watched. Cyril Fisher,Khin Thway Royal Marsden Hospital, London, United Kingdom.

Dec 2013
Revised Feb 2014

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Considerations for tissue expansion in the management of massive dermatofibrosarcoma protuberans of the head and neck. Dermatofibrosarcoma protuberans (DFSP) is a locally invasive soft tissue tumor with rare malignant potential, but a high tendency for local recurrence. We present 2 cases of DFSP involving the head and neck requiring tissue expansion for reconstruction. Austin M Badeau,Frederic W-B Deleyiannis,Mark Granick Division of Plastic Surgery, Department of Surgery, Rutgers New Jersey Medical School, Newark.,Division of Plastic Surgery, Departments of Surgery and Otolaryngology, University of Colorado Hospital & Children's Hospital Colorado, Aurora.,University of Colorado School of Medicine, MSIV, Aurora.

Jan 2014

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Desmoid tumor-associated pain is dependent on mast cell expression of cyclooxygenase-2. This study aimed to investigate the expression profile of cyclooxygenase-2 (COX-2) in desmoid tumor specimens and to evaluate the correlation of intratumoral COX-2 expression with pain status. Our results indicated that COX-2 secretion from mast cells modulates desmoid tumor-associated pain. In addition, mast cells may at least in part contribute to the pathogenesis of desmoid tumors. Hiroko Asanuma,Makoto Emori,Mitsunori Kaya,Tomoko Mitsuhashi,Toshihiko Yamashita

Jan 2014

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A prospective multicenter phase II study of sunitinib in patients with advanced aggressive fibromatosis. Several studies have reported that imatinib may induce tumor responses and prolonged disease stabilization in aggressive fibromatosis (AF). This effect may relate to the PDGFR-β pathway and KIT mutations. The aim of this prospective multicenter uncontrolled study was to evaluate the efficacy and safety of sunitinib in patients with advanced AF. Most of the primary sites were intra-abdominal (12, 63.2 %), and AF associated with familial adenomatous polyposis in ten patients (52.6 %). Grade 3 or 4 adverse events of sunitinib that occurred in >5 % of patients were neutropenia (33.3 %), diarrhea (5.3 %), and hand-foot syndrome (5.3 %). In 3 of 12 patients with mesenteric AF, mesenteric mass bleeding (n = 1), bowel perforation (n = 1), and bowel fistula (n = 1) with tumor mass necrosis were observed early during sunitinib treatment. Therefore, sunitinib showed potential antitumor activity and may be useful for the management of non-mesenteric AF. Jae-Cheol Jo,Jae-Lyun Lee,Jeeyun Lee,Jin-Sook Ryu,Jong-Seok Lee,Kyu-Pyo Kim,Sun Young Kim,Tae Won Kim,Yong Sang Hong,Young Suk Park Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Korea.

Jan 2014

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Percutaneous Image-Guided Cryoablation in Inoperable Extra-abdominal Desmoid Tumors: A Study of Tolerability and Efficacy. Despite high rates of partial ablation, percutaneous image-guided cryoablation appears to be safe and effective for local control for patients with inoperable extra-abdominal desmoid tumors. A Gangi,A Italiano,E Stoeckle,F Cornelis,M Havez,M Kind,N Lippa,O Hauger,S Al-Ammari Department of Radiology, Hôpital Pellegrin, CHU de Bordeaux, Place Amélie Raba Léon, 33076, Bordeaux, France.

Jan 2014

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Nuclear expression of β-catenin predicts the efficacy of meloxicam treatment for patients with sporadic desmoid tumors. This study aimed to determine the prevalence of β-catenin nuclear positivity as a prognostic factor in patients with desmoid tumors (DTs) treated with meloxicam, a cyclooxygenase-2 (COX-2) selective inhibitor. Between 2003 and 2012, consecutive 31 patients with extraabdominal, sporadic DTs were prospectively treated with meloxicam as a systemic medical therapy. The nuclear expression of β-catenin can predict the efficacy of meloxicam treatment for patients with sporadic Dts. Eiji Kozawa,Hiroshi Urakawa,Kunihiro Ikuta,Naohisa Futamura,Naoki Ishiguro,Shigeo Nakamura,Shunsuke Hamada,Yoshie Shimoyama,Yoshihiro Nishida Department of Orthopedic Surgery, Nagoya University Graduate School and School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi, 466-8550, Japan.

Nov 2013
Revised Jan 2014

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Aggressive desmoplastic fibromatosis - a clinicians dilemma case report and review of literature. A rare case of aggressive desmoplastic fibromatosis in a 12-year-old girl is presented in this article with emphasis on the need and challenges for diagnosing such lesions as they have to be differentiated from other soft tissue tumors which display borderline pathological features regarding benign or malignant behaviour. Adesh S Manchanda,Balwinder Singh,Preeti Chawla Arora,Ramandeep S Narang,Satinder Walia Professor, Department of Oral & Maxillofacial Pathology, Sri Guru Ram Das Institute of Dental sciences & Research , Amritsar, Punjab, India .,Reader, Department of Oral Medicine & Radiology, Sri Guru Ram Das Institute of Dental sciences & Research , Amritsar, Punjab, India .,Senior Lecturer, Department of Community Dentistry, Sri Guru Ram Das Institute of Dental sciences & Research , Amritsar, Punjab, India .,Senior Lecturer, Department of Oral & Maxillofacial Pathology, Sri Guru Ram Das Institute of Dental sciences & Research , Amritsar, Punjab, India .,Senior Lecturer, Department of Oral Medicine & Radiology, Sri Guru Ram Das Institute of Dental sciences & Research , Amritsar, Punjab, India .

Oct 2013
Revised Jan 2014

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Desmoid Tumor Formation following Posterior Spinal Instrumentation Placement. The objective of the article is to illustrate a case of desmoid tumor (DT) formation after posterior instrumentation of the thoracic spine. One must consider the possibility of a DT in the setting of reported surgical site fullness or mass after spine surgery. It is thought that postoperative inflammation present in the surgical bed may promote formation of DTs. Instrumentation may also contribute to inflammation and increase the likelihood of developing a DT. Ioan A Lina,Jason A Liauw,Peter C Burger,Timothy F Witham,Varun Puvanesarajah,Wesley Hsu Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.,Department of Neurosurgery, Wake Forest University Baptist Medical Center, Baltimore, Maryland, United States.

Jan 2013
Revised Jan 2014

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Abdominal Wall Synovial Sarcoma During Pregnancy-a Case Report. We report a 21-year-old woman with synovial sarcoma on anterior abdominal wall at 34th week of gestation, which was clinically diagnosed as desmoid tumor. Tumor was totally excised. After 6 months, it relapsed in the form of multiple abdominal wall swellings and ascites. Hemlata Kamra,Pradeep A Gadgil,Shivaji D Birare,Suresh A Chaware,Umesh S Kanade Department of Pathology, Government Medical College and General Hospital, Latur, Maharashtra 413512 India.

Jun 2012
Revised Jan 2014

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Desmoid infilterating ileum, a rare complication. Desmoid tumors are benign, but may infiltrate adjacent structures. Rarely severe and fatal, clinical problems are seen if mesenteric vessels or abdominal organs are involved. Ileum is one of the rare sites and literature search regarding this yielded scant results. Hence, we decided to report this case of aggressive desmoid tumors of the abdominal wall infiltrating ileum. Mandar Dhamangoankar,Ramakant Baloorkar,Tejaswini Vallabha,Uday Karjol,Vikram Sindgikar Aniketan Nursing Home, KK Nagar Bagewadi Road, Bijapur, Karnataka 586109 India.,Department of General Surgery, BLDEU'SShri B.M. Patil Medical College, Bijapur, Karnataka India.

Jun 2012
Revised Jan 2014

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Primary mesenteric fibromatosis: a case report with brief review of literature. Here, we discuss one case of primary mesenteric fibromatosis in a young male patient who presented to us with chronic abdominal pain after he was treated for acid peptic disease for the same at a local hospital. This case shows how management of this disease can be delayed due to unfamiliarity among clinicians of this condition. Geeta Karbeet Radhakrishna,Harpreet Singh,P R Bhat,Rajgopal K Shenoy,Srinivas Pai Department of Surgery, Kasturba Medical College Hospital, Manipal University, Manipal, Karnataka India 576104.

Dec 2013

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Pancreatic solid cystic desmoid tumor: case report and literature review. This paper describes a case of a sporadic cystic DT of the pancreas managed successfully with central pancreatectomy, with no signs of recurrence 40 mo after surgery. Bin Xu,Erik Matro,Jia-Guo Wu,Jun-Jun Ni,Ling-Hua Zhu,Xian-Fa Wang Bin Xu, Ling-Hua Zhu, Xian-Fa Wang, Erik Matro, Jun-Jun Ni, Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, Zhejiang Province, China.

Dec 2013

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Sporadic desmoid-type fibromatosis: a stepwise approach to a non-metastasising neoplasm--a position paper from the Italian and the French Sarcoma Group. Desmoid-type fibromatosis (DF) is a rare locally aggressive monoclonal proliferation of myofibroblasts lacking metastatic capacity. It may be observed in nearly every part of the body. Considering the unpredictable behavior and the heterogeneity of this disease, we propose a treatment algorithm approved by the French and the Italian Sarcoma Group, based on a front-line wait and see approach and subsequent therapy in the case of progression. A Gronchi,A Le Cesne,A Marrari,A P Dei Tos,C Colombo,C Le Péchoux,C Mussi,E Stoeckle,F Duffaud,F Gherlinzoni,F Gouin,G Grignani,J Y Blay,M Fiore,N Penel,P G Casali,P Meeus,S Bonvalot Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Dec 2013

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A Novel APC Gene Mutation Associated With a Severe Phenotype in a Patient With Turcot Syndrome. Turcot syndrome is a rare inherited condition of colonic polyposis associated with central nervous system tumors. Multiple tumors may be seen in patients with Turcot syndrome but the occurrence of sarcomas is rare. This case highlights the importance of close follow-up for patients with Turcot syndrome and the importance of a broad differential diagnosis in evaluating a condition in which multiple tumors are frequently seen. Beth A C Hall,Christopher L Moertel,Joanna S Yi,Stephanie A Fritch Lilla *Department of Pediatrics, University of Minnesota †Children's Hospitals and Clinics of Minnesota, Minneapolis, MN.

Dec 2013

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Multivisceral transplantation for the treatment of intra-abdominal tumors. Although large intra-abdominal desmoid tumors, well-differentiated neuroendocrine tumors, and gastrointestinal stromal tumors are slow growing, they tend to invade locally, especially to the mesenteric root and/or celiac axis and other abdominal viscera. Complete resection followed by multivisceral transplantation could be a therapeutic option for these advanced tumors. A Bahreini,A Shamsaeefar,K Kazemi,M Aliakbarian,S A Malekhosseini,S Nikeghbalian Department of Surgery, Namazi Hospital, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Dec 2013

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Rare case of desmoid-type fibromatosis of the mandibular region in a child: diagnosis and surgical management. A case is reported of a 8-year- old girl with desmoid fibroma in the mandible who presented at the Department of Pediatric Dentistry with a swelling measuring 4x4 cm on the lower edge of the right mandible which had appeared a few months earlier and slowly developed. D Burlini,E Bardellini,F Amadori,G Conti AO Spedali Civili Brescia, Dep. Pediatric Maxillo Facial Surgery, Brescia, Italy.

 Dec 2013

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Pelvic deformity secondary to tensor fascia lata tightness associated with desmoid tumor. The authors present a rare case of a hip contracture in a 28-year-old active man who presented with a functionally disabling hip flexion contracture of 20° with further flexion possible up to 130°, a 45° abduction contracture, and a 20° external rotation contracture with further rotation possible up to 40° with a bony hard swelling in the left gluteal region. Opposite hip and spine examinations were normal. The goals of treatment were to establish the causality between the 2 and to diagnose the etiology of the gluteal mass. Radiographs were normal, with only a pelvic obliquity evident. Magnetic resonance imaging revealed an extra-articular mass abutting the iliac blade. Histopathology confirmed the mass to be a desmoid tumor in the left gluteal region. A wide surgical excision of the mass was performed with negative margins; no postoperative radiotherapy was administered. After rigorous physiotherapy, the hip deformity disappeared at 6 months and there was no evidence of recurrence at 2.5-year follow-up, with the patient able to sit cross-legged and squat. Anoop C Dhamangaonkar,Arvind B Goregaonkar,Deepak Joshi,Mukesh Phalak

Dec 2013

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[Sarcomas, example of a pathologist network organization]. Sarcomas are rare and heterogeneous with many subtypes explaining the high level of diagnostic difficulty with frequent important therapeutic consequences. In 2009, a national network of pathologists has been set up with the main objective to perform a systematic histological review of every new sarcoma, gastro-intestinal stromal tumor (GIST) and desmoid tumor. We describe the network organization and report the results of the first two years of activity. Agnes Neuville,Jean-Michel Coindre Université Victor-Ségalen, institut Bergonié, département de pathologie, laboratoire d'anatomie pathologie et Inserm U916, 229, cours de l'Argonne, 33076 Bordeaux Cédex, France.

Nov 2013

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Expression of FAP, ADAM12, WISP1, and SOX11 is heterogeneous in aggressive fibromatosis and spatially relates to the histologic features of tumor activity. Aggressive fibromatosis (AF) represents a group of tumors with a variable and unpredictable clinical course, characterized by a monoclonal proliferation of myofibroblastic cells. Identification and validation of genes whose expression patterns are associated with AF may elucidate biological mechanisms in AF, and aid treatment selection. This study was designed to examine the protein expression by immunohistochemistry (IHC) of four genes, ADAM12, FAP, SOX11, and WISP1, that were found in an earlier study to be uniquely overexpressed in AF compared with normal tissues. Amy P N Skubitz,Benjamin S Misemer,Christopher L Corless,Edward Y Cheng,J Carlos Manivel,Jonathan C Henriksen,Joseph S Koopmeiners,Keith M Skubitz,Stephen C Schmechel Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota; Masonic Cancer Center, University of Minnesota Medical School, Minneapolis, Minnesota.

Nov 2013

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Pazopanib is an active treatment in desmoid tumour/aggressive fibromatosis. We report the outcome of two patients affected by progressive DT/AF treated with the angiogenesis inhibitor pazopanib in two different institutions. Both patients achieved dramatic improvement in their symptoms and radiological signs of response. The clinical benefit lasted for more than 1 year and it is still ongoing. Charlotte Benson,Christina Messiou,Heather McCarty,Ian Judson,Juan Martin-Liberal,Khin Thway The Royal Marsden Hospital, Sarcoma Unit, Fulham Road, SW3 6JJ London, UK. juan.martin@rmh.nhs.uk.

Nov 2013

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Stromal signatures in endometrioid endometrial carcinomas. The pattern of myometrial invasion in endometrioid endometrial carcinomas varies considerably; ie, from widely scattered glands and cell nests, often associated with a fibromyxoid stromal reaction (desmoplasia) and/or a lymphocytic infiltrate, to invasive glands with little or no stromal response. Recently, two distinct stromal signatures derived from a macrophage response (colony-stimulating factor 1, CSF1) and a fibroblastic response (desmoid-type fibromatosis, DTF) were identified in breast carcinomas and correlated with clinicopathologic features including outcome. In this study, we explored whether these stromal signatures also apply to endometrioid carcinomas and how their expression patterns correlated with morphologic changes. Ana Mozos,Cristina Bértolo,Emanuela D Angelo,Gian Franco Zannoni,Iñigo Espinosa,Irene Ferrer,Jaime Prat,Lluis Catasus,Matt van de Rijn,Nuria Pedrola,Robert B West,Xavier Matias-Guiu Department of Pathology, Hospital de la Santa Creu i Sant Pau, Institute of Biomedical Research (IIB Sant Pau), Autonomous University of Barcelona, Barcelona, Spain.

Nov 2013

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Uncommon perineal tumours: caution with aggressive surgical management. An asymptomatic 66-year-old woman showed a large perineal mass extending close to pelvic organs on MRI. CT-guided needle biopsies revealed a desmoid tumour (DT). The patient refused radical surgery. Four years later, the tumour had marginally increased in size and was still asymptomatic. Elisabeth Cassagnau,Emilie Duchalais,Guillaume Meurette,Nicolas Regenet Department of Digestive and Endocrine Surgery, University Hospital of Nantes, Nantes, France.

Nov 2013

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Aggressive fibromatosis of the head and neck in the pediatric population. Aggressive fibromatosis, previously referred to as desmoid tumor, is a rare tumor. It is classified as benign, however, has a high potential for local invasion and recurrence. It is most commonly found in the abdomen, with an origin in the head and neck accounting for less than a quarter of the total cases. Anita Jeyakumar,Hugo StHilaire,Sarah Peña,Todd Brickman Department of Otorhinolaryngology, Louisiana State University-Health Science Center, 533 Bolivar Street Suite 566, New Orleans, LA 70112, USA.,Department of Otorhinolaryngology, Louisiana State University-Health Science Center, 533 Bolivar Street Suite 566, New Orleans, LA 70112, USA. Electronic address: ajeyak@lsuhsc.edu.,Department of Plastic Surgery, Louisiana State University-Health Science Center, New Orleans, LA 70112, USA.

Nov 2013

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Desmoplastic fibroma arising in the distal phalanx of the great toe: a case report. Desmoplastic fibroma (DF) of the bone is a rare locally aggressive tumor usually occurring in adolescents and young adults. These tumors most commonly occur in the mandibles and metaphyses of long bones but are extremely rare in small bones, often resulting in diagnostic problems. The occurrence of these tumors in the foot is especially limited. We report the clinical, radiographic, and histologic features of DF arising in the distal phalanx of the great toe and a review of the published data. Hideo Morioka,Hiroo Yabe,Itsuo Watanabe,Keisuke Horiuchi,Makio Mukai,Michiro Susa,Robert Nakayama,Takeshi Koba,Yoshiaki Toyama Department of Diagnostic Pathology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.,Department of Orthopaedic Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.,Department of Orthopaedic Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan. Electronic address: msusa@z6.keio.jp.

Nov 2013

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Desmoid-type fibromatosis of the head and neck region in the paediatric population: a clinicopathological and genetic study of seven cases. Desmoid-type fibromatosis (desmoid) is a locally aggressive (myo)fibroblastic lesion. It represents one of the more common fibrous tumours in children and adolescents. The head and neck region is more often involved than in adults. Our study provides evidence of genetic similarities in desmoid and desmoplastic fibroma. Additionally, we expanded the spectrum of mutations in CTNNB1 with one novel desmoid mutation. Bastiaan B J Tops,Paul J van Diest,Pieter J Slootweg,Uta Flucke Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

Nov 2013

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Desmoplastic fibroma of bone in a toe: radiographic and MRI findings. Desmoplastic fibroma is a rare benign primary bone tumor that is histologically similar to the soft tissue desmoid tumor. It most often involves the mandible, large long bone or iliac bone. Desmoplastic fibroma in a toe has been extremely rarely reported. Hye Jung Choo,In Sook Lee,Ji Hwa Ryu,Ji Yeon Kim,Kyung Jin Suh,Ok Hwa Kim,Seon Jeong Kim,Sun Joo Lee Department of Radiology, Inje University, Haeundae Paik Hospital, Busan 612-896, Korea.

Nov 2013

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[A case of familial adenomatous polyposis presenting with thyroid cancer]. We report a case of familial adenomatous polyposis( FAP) presenting with thyroid cancer. A 24-year-old woman, on histological examination, was diagnosed as having the cribriform-morular variant of papillary thyroid carcinoma, which is known to be associated with FAP. After total thyroidectomy, total proctocolectomy and excision of the tumor arising from the mesentery of the small intestines were performed. The histological diagnosis was FAP with a desmoid tumor arising from the mesentery. Eiji Noda,Hiroaki Tanaka,Hiroshi Ohtani,Hisashi Nagahara,Kazuya Muguruma,Kenjiro Kimura,Kiyoshi Maeda,Kosei Hirakawa,Mamiko Takii,Masaichi Ohira,Masatsune Shibutani,Naoshi Kubo,Naoyoshi Onoda,Ryosuke Amano,Takahiro Toyokawa,Takuya Higashiyama Dept. of Surgical Oncology, Osaka City University Graduate School of Medicine.

Oct 2013

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Insulin-like growth factor II messenger RNA-binding protein 3 expression in gastrointestinal mesenchymal tumors. Insulin-like growth factor II messenger RNA-binding protein 3 (IMP3) is a recently identified biomarker demonstrated to be useful in diagnosis and prognostic prediction for several kinds of malignant tumors. In this study, we examined the immunohistochemical expression of IMP3 in gastrointestinal stromal tumor (GIST) (n = 150), malignant melanoma (n = 17), malignant mesothelioma (n = 6), leiomyosarcoma (n = 6), inflammatory myofibroblastic tumor (IMT) (n = 12), desmoid fibromatosis (n = 8), leiomyoma (n = 20), and schwannoma (n = 20). GIST, desmoid fibromatosis, leiomyoma and schwannoma, were essentially negative for IMP3. Aya Fujita,Hidetaka Yamamoto,Junichi Motoshita,Katsumi Arakaki,Katsuya Morimatsu,Kenichi Kohashi,Minako Hirahashi,Yoko Zaitsu,Yoshinao Oda,Yumi Oshiro Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.,Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address: hidetaka@surgpath.med.kyushu-u.ac.jp.,Department of Pathology, Hamanomachi Hospital, Fukuoka 810-8539, Japan.,Department of Pathology, Matsuyama Red Cross Hospital, Matsuyama 790-8524, Japan.

Oct 2013

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A giant pregnancy-associated intra-abdominal desmoid tumour: not necessarily a contraindication for subsequent pregnancy. Although rarely located in the abdomen, pregnancy-associated desmoid tumours should be included in the differential diagnosis of intra-abdominal tumours detected during or shortly after pregnancy. Based on this case and a few others reported in the literature, subsequent pregnancy does not necessarily seem to be a risk factor for recurrent or new disease. Eelco de Bree,Elpida Giannikaki,Eustathios Dimitriadis,Evangelia G Chryssou,John Melissas Department of Surgical Oncology, Medical School of Crete University Hospital, Heraklion, Greece. debree@edu.uoc.gr.

Oct 2013

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Desmoid-Type Fibromatosis and Pregnancy: A Multi-institutional Analysis of Recurrence and Obstetric Risk. Many women who present with desmoid-type fibromatosis (DF) have had a recent pregnancy. A cohort of women with DF and pregnancy was identified from 4 sarcoma centers. Progression/regression rates, recurrence rates after resection, and obstetric outcomes were analyzed. Pregnancy-related DF has good outcomes. Progression risk during pregnancy is high, but it can be safely managed. DF does not increase obstetric risk, and it should not be a contraindication to future pregnancy. Alessandro Gronchi,Amanda J Cannell,Axel Le Cesne,Carol J Swallow,Chandrajit P Raut,Chiara Colombo,Marco Fiore,Monica M Bertagnolli,Paolo G Casali,Rebecca A Gladdy,Sara Coppola,Suzanne George,Sylvie Bonvalot *Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy †Department of Surgery, Institut Gustave Roussy, Villejuif, France ‡Division of General Surgery, Mount Sinai Hospital; Department of Surgical Oncology, Princess Margaret Hospital; and Department of Surgery, University of Toronto, Toronto, Ontario, Canada §Department of Surgery, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA ¶Department of Medical Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA ‖Department of Medical Oncology, Institut Gustave Roussy, Villejuif, France **Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Oct 2013

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Prognostic factors influencing event-free survival and treatments in desmoid-type fibromatosis: analysis from a large institution. This study demonstrates that tumor size and a history of recurrence are independent predictors of EFS. Surgery is warranted if it can be R0 and function sparing. Nonsurgical modalities or a policy of watchful waiting may be a better choice for unresectable disease. Chun Meng Wang,Chun Yan Du,Hong Fu,Jing Gui Chen,Kai Huang,Ye Zhou,Ying Qiang Shi Department of Gastric Cancer and Sarcomas, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College of Fudan University, No. 270 Dong An Road, Shanghai 200032, China.

Sep 2013

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Desmoid tumors of the head and neck: A therapeutic challenge. Desmoid tumor, or aggressive fibromatosis, is a rare, histologically benign, fibroblastic lesion that infrequently presents in the head and neck. The most common treatment is surgery, but desmoid tumors are characteristically associated with a high local recurrence rate after resection. The efficacy of postoperative radiotherapy is controversial. Its potential benefit should be carefully balanced against possible radiation-induced adverse effects. Alternative treatment modalities, such as primary radiotherapy and medical treatment or a wait-and-see policy, may be preferable to mutilating surgery. Alessandra Rinaldo,Alfio Ferlito,Ashok R Shaha,Carlos Suárez,Eelco de Bree,Jennifer L Hunt,Juan P Rodrigo,Michael L Hinni,Odysseas Zoras,Remco de Bree,Robert P Takes,William M Mendenhall Department of Surgical Oncology, Medical School of Crete University Hospital, Heraklion, Greece.

Sep 2013

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Desmoid Tumor arising from Omohyoid Muscle: The First Report for Unusual Complication after Trans-axillary Robotic Thyroidectomy. We describe a rare case of a desmoid tumor developed after TAR thyroidectomy, which is speculated to be a late-term complication. Heejin Kim,Il Gyu Kong,J Hun Hah,Myung-Whun Sung,Wonjae Cha Department of Otorhinolaryngology - Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea.

 Sep 2013

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The clinical effect of a positive surgical margin and adjuvant postoperative radiotherapy in the treatment of resectable desmoid tumors. The aim of this study was to investigate the characteristics and outcomes of patients with resectable DTs. A total of 21 patients were included and their clinicopathological characteristics were retrospectively analyzed. The median relapse-free survival (RFS) was 20.5 months for the patients treated by surgery alone and 50 months for those treated with surgery followed by adjuvant RT (P>0.05). Age, gender, SM and adjuvant RT were not identified as predictors of recurrence. No predictive factors appeared to indicate local DT recurrence following surgery. Fulya Agaoglu,Harzem Ozger,Meltem Ekenel,Mert Basaran,Senem Karabulut,Serkan Keskin,Sevil Bavbek Department of Orthopedics and Traumatology, Faculty of Medicine, Istanbul University, 34390 Istanbul, Turkey.,Departments of Medical Oncology, Istanbul University, 34390 Istanbul, Turkey.,Radiation Oncology, Institute of Oncology, Istanbul University, 34390 Istanbul, Turkey.

Aug 2013

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Desmoid tumors: a comprehensive review of the evolving biology, unpredictable behavior, and myriad of management options. Desmoid tumors are rare, clonal collections of benign fibrous tissue that exhibit a highly variable clinical course. This article presents a comprehensive review of desmoid tumors and summarizes the current literature pertaining to clinical presentation, diagnostic modalities, pathogenesis, prognostic factors, and management options. Rashmi Chugh,Sumana Devata Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, C407 Med Inn Building, 1500 East Medical Center Drive, SPC 5848, Ann Arbor, MI 48109-5848, USA.
2013 A multidisciplinary approach to desmoid tumors. When intra-abdominal fibromatosis degenerates into an abscess, which is the right treatment? Alemanno G, Zambonin D, Sturiale A, Cavalli T, Bellucci F, Pesi B, Di Martino C, Giudici F, Tonelli F. Digestive Surgery Unit, Department of Clinical Physiopathology, University of Florence Medical School, Careggi University Hospital, Florence, Italy. Link to Article
2013 Spontaneous Regression of Primary Abdominal Wall Desmoid Tumors: More Common than Previously Thought Bonvalot S, Ternès N, Fiore M, Bitsakou G, Colombo C, Honoré C, Marrari A, Le Cesne A, Perrone F, Dunant A, Gronchi A. Department of Surgery, Gustave Roussy Institute, Villejuif, Franc Link to Article
2013 Desmoid Tumor arising from Omohyoid Muscle: The First Report for Unusual Complication after Trans-axillary Robotic Thyroidectomy Cha W, Kong IG, Kim H, Hah JH, Sung MW. Department of Otorhinolaryngology - Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea. Link to Article
2013 A rare presentation of a large extra-abdominal desmoid tumor of the posterior neck and back. Chu KF, Samara MS, Laver N, Wein RO The Warren Alpert Medical School of Brown University, Providence, RI, USA Link to Article
2013 CTNNB1 45F mutation is a molecular prognosticator of increased postoperative primary desmoid tumor recurrence: An independent, multicenter validation study. Colombo C, Miceli R, Lazar AJ, Perrone F, Pollock RE, Le Cesne A, Hartgrink HH, Cleton-Jansen AM, Domont J, Bovée JV, Bonvalot S, Lev D, Gronchi A. Sarcoma Service, Department of Surgery, Scientific Institute for Research, Hospitalization, and Health Care (IRCCS) Foundation, National Cancer Institute, Milan, Italy. Link to Article
2013 Desmoid Tumors: A Comprehensive Review of the Evolving Biology, Unpredictable Behavior, and Myriad of Management Options. Devata S, Chugh R. Desmoid Tumors: A Comprehensive Review of the Evolving Biology, Unpredictable Behavior, and Myriad of Management Options. Link to Article
2013 Abdominoplasty access for desmoid tumor resection in the rectus abdominis muscle. Djedovic G, Verstappen R, Pierer G, Rieger UM. Department of Plastic, Reconstructive and Aesthetic Surgery, Innsbruck Medical University, Innsbruck, Austria. Link to Article
2013 Complex reconstruction of desmoid tumor resections does not increase desmoid tumor recurrence. Garvey PB, Booth JH, Baumann DP, Calhoun KA, Liu J, Pollock RE, Butler CE. Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX. Link to Article
2013 Targeting stem cell behavior in desmoid tumors (aggressive fibromatosis) by inhibiting hedgehog signaling. Ghanbari-Azarnier R, Sato S, Wei Q, Al-Jazrawe M, Alman BA. Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada. Link to Article
2013 Desmoid tumor following augmentation mammoplasty with silicone implants. Jeong WS, Oh TS, Sim HB, Eom JS. Department of Plastic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. Link to Article
2013 Desmoid tumour of the brachial plexus. Juliette O, Florentius K, Francis N, Macharia BN, Neema M. Department of Radiology, Moi University School of Medicine, P.O. Box 4606, Eldoret 30100, Kenya. Link to Article
2013 Results of a phase II pilot study of moderate dose radiotherapy for inoperable desmoid-type fibromatosis--an EORTC STBSG and ROG study (EORTC 62991-22998). Keus RB, Nout RA, Blay JY, de Jong JM, Hennig I, Saran F, Hartmann JT, Sunyach MP, Gwyther SJ, Ouali M, Kirkpatrick A, Poortmans PM, Hogendoorn PC, van der Graaf WT. Arnhem Radiotherapy Institute, Arnhem. Link to Article
2013 Desmoid type fibromatosis in the facet joint of lumbar spine: case report and review of literature. Kim SJ, Ha DH, Lee SM, Kang H. Department of Radiology, CHA Bundang Medical Center, CHA University, Seongnam 463-712, Korea. Link to Article
2013 Lipomatosis of the sciatic nerve secondary to compression by a desmoid tumor. Lee CH, Wu JS, Goldsmith JD, Kung JW. Department of Radiology, Wan Fang Hospital, Taipei Medical University, 111 Hsing-Long Road, Section 3, Taipei 116, Taiwan, Republic of China, Link to Article
2013 Abdominal wall desmoid tumors: A case report. Ma JH, Ma ZH, Dong XF, Yin H, Zhao YF. Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China. Link to Article
2013 ß-Catenin Mutation Status and Outcomes in Sporadic Desmoid Tumors. Mullen JT, Delaney TF, Rosenberg AE, Le L, Iafrate AJ, Kobayashi W, Szymonifka J, Yeap BY, Chen YL, Harmon DC, Choy E, Yoon SS, Raskin KA, Hornicek FJ, Nielsen GP. Link to Article
2013 Imaging features of desmoid-type fibromatosis in the teres major muscle. Nishio J, Aoki M, Nabeshima K, Iwasaki H, Naito M. Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. Link to Article
2013 An intra-abdominal desmoid tumor difficult to distinguish from a gastrointestinal stromal tumor: report of two cases. Ogawa N, Iseki H, Tsunozaki H, Hayashi M, Baba H, Matsuyama T, Uetake H, Sugihara K Department of Surgical Oncology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan Link to Article
2013 Preventing neurovascular invasion in desmoid tumors. Ozger H, Ozkunt O, Akgül T, Saglam Y. Department of Orthopaedics and Traumatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. Link to Article
2013 Aggressive fibromatosis (desmoid tumour) of the head and neck: a benign neoplasm with high recurrence. Prabhu R, Natarajan A, Shenoy R, Vaidya K. Department of General Surgery, Kasturba Medical College, Manipal, Karnataka, India. Link to Article
2013 Surgical resection and radiation therapy of desmoid tumours of the extremities: results of a supra-regional tumour centre. Prodinger PM, Rechl H, Keller M, Pilge H, Salzmann M, von Eisenhart-Rothe R, Holzapfel BM. Department of Orthopedic Surgery, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675, Munich, Germany, Link to Article
2013 Recurrence patterns and management options in aggressive fibromatosis. Ramamurthy R, Arumugam B, Ramanandham B. Department of Surgical oncology, Govt. Royapettah hospital, Kilpauk medical college, Chennai, Tamil Nadu 600014 India Link to Article
2013 Extra-abdominal Periosteal Desmoid Tumor of the Third Toe. Saleem O, Sayres S, O'Malley M. Link to Article
2013 Surgical treatment of pediatric desmoid tumors. A 12-year, single-center experience. Soto-Miranda MA, Sandoval JA, Rao B, Neel M, Krasin M, Spunt S, Jenkins JJ, Davidoff AM, Ver Halen JP. Department of Plastic Surgery, University of Tennessee, Memphis, TN, USA. Link to Article
2013 Benign soft tissue tumors in children. Thacker MM. Department of Orthopedic Surgery, Nemours-Alfred I duPont Hospital for Children, 1600 Rockland Road, Wilmington, DE Link to Article
2013 Local recurrence after surgery for primary extra-abdominal desmoid-type fibromatosis. van Broekhoven DL, Verhoef C, Elias SG, Witkamp AJ, van Gorp JM, van Geel BA, Wijrdeman HK, van Dalen T. Department of Surgery, Diakonessenhuis Utrecht, Utrecht, The Netherlands. Link to Article
2013 An abdominal desmoid-type fibromatosis. Wang Y, Cui NY, Li L, Zhang R, Hao YZ, Xue LY, Zhou CW, Jiang YX. Department of Diagnostic Imaging, Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences,Beijing 100142, China; Link to Article
2013 Vinblastine and methotrexate for desmoid fibromatosis in children: results of a Pediatric Oncology Group Phase II Trial. Williams KJ, Hayes AJ. Academic Section of Vascular Surgery, Imperial College London, London, UK Link to Article
2013 Small bowel obstruction in patients with familial adenomatous polyposis-related desmoid disease. Xhaja X, Church J. Sanford R. Weiss MD Center for Hereditary Colorectal Neoplasia, Department of Colorectal Surgery, Digestive Diseases Institute, Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, Ohio, Link to Article
2013 Enterocutaneous fistulas in familial adenomatous polyposis patients with abdominal desmoid disease. Xhaja X, Church J. Sanford R. Weiss MD Center for Hereditary Colorectal Neoplasia, Department of Colorectal Surgery, Digestive Diseases Institute, Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, Ohio, Link to Article
2013 Positron Emission Tomography as a Surrogate Marker for Evaluation of Treatment Response in Patients with Desmoid Tumors under Therapy with Imatinib. Kasper B, Dimitrakopoulou-Strauss A, Pilz LR, Strauss LG, Sachpekidis C, Hohenberger P. Sarcoma Unit, ITM-Interdisciplinary Tumor Center Mannheim, Mannheim University Medical Center, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. Link to Article
2013 Desmoid: The Role of Local Therapy In an Era of Systemic Options. Walczak BE, Rose PS. Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA. Link to Article
2013 Giant desmoid tumor of the anterior abdominal wall in a young female: a case report. Koshariya M, Shukla S, Khan Z, Vikas V, Pratap Singh A, Baghel P, Pendro V, Kirti Jain V, Jagdish Jai S, Kumar S, Songra MC Department of Surgery, Gandhi Medical College & Associated Hamidia Hospital, Bhopal 462001, India. Link to Article
2013 Desmoid tumors in children: current strategy. Oudot C, Defachelles AS, Minard-Colin V, Olschwang S, Fourcade L, Helfre S, Orbach D. CHU de Limoges, hôpital de la Mère et de l'Enfant, service d'oncologie pédiatrique, 8, avenue Dominique-Larrey, 87042 Limoges, France. Link to Article
2013 Isolated desmoid tumor of pancreatic tail with cyst formation diagnosed by Beta-catenin immunostaining : a rare case report with review of literature. Rao, R.N. Associate Professor, Department of Pathology,Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raibarely Road Lucknow,UP,India. Link to Article
2013 Aggressive fibromatosis of the head and neck in pediatric age. A case report and review of the literatur Morillo C, Ruiz Dieguez PR, Navarro M, Galeas Anaya FJ, Ruiz Delgado F, Valiente Alvarez A, Bermudo Añino L. Servicio de Cirugía Oral y Maxilofacial, Hospital Regional Universitario Carlos Haya, Málaga Link to Article
2013 Desmoid Tumor of the Hand: A Case Report. Maher J, Smith DA, Parker WL. From the *Division of Plastic Surgery, and †Department of Pathology, Scott & White Healthcare and Texas A&M Health Science Center, Temple, TX. Link to Article
2013 Cardiac failure due to a giant desmoid tumour of the posterior mediastinum. Bouchikh M, Arame A, Riquet M, Le Pimpec-Barthes F. Department of Thoracic Surgery, Georges Pompidou European Hospital, Descartes University, Paris, France. Link to Article
2013 Surgical Outcome of Desmoid Tumors: Adjuvant Radiotherapy Delayed the Recurrence, But Did Not Affect Long-Term Outcomes. Shin SH, Ko KR, Cho SK, Choi YL, Seo SW. Department of Orthopaedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. Link to Article
2013 Nuclear GSK-3ß segregation in desmoid-type fibromatosis. Meneghello C, Ousghir B, Rastrelli M, Anesi L, Sommariva A, Montesco MC, Rossi CR, Hladnik U, Segat D. Genetics Unit, 'Mauro Baschirotto' Institute for Rare Diseases, Vicenza, Italy.
2013 Local control of extra-abdominal desmoid tumors: systematic review and meta-analysis. Wood TJ, Quinn KM, Farrokhyar F, Deheshi B, Corbett T, Ghert MA. Michael G. DeGroote School of Medicine, ; Department of Surgery. Link to Article
2013 Positron Emission Tomography as a Surrogate Marker for Evaluation of Treatment Response in Patients with Desmoid Tumors under Therapy with Imatinib. Kasper B, Dimitrakopoulou-Strauss A, Pilz LR, Strauss LG, Sachpekidis C, Hohenberger P. Sarcoma Unit, ITM-Interdisciplinary Tumor Center Mannheim, Mannheim University Medical Center, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany Link to Article
2013 Case report: metachronous central nervous system desmoid tumours and thyroid carcinoma in a young familial adenomatous polyposis patient. Butel-Simoes GI, Spigelman AD. University of New South Wales, Sydney, NSW, Australia Link to Article
2013 Huge desmoid tumor of the anterior abdominal wall mimicking an intraabdominal mass in a postpartum woman: a case report. Trigui K, Bouassida M, Kilani H, Mighri MM, Sassi S, Chebbi F, Touinsi H, Sassi S. Department of surgery, MTM Hospital, Nabeul, Tunisia. Link to Article
2013 Successful outcome after laparoscopic surgery for sporadic colonic desmoid tumor with β-catenin mutation: a case report. Gunji S, Kawada K, Kawada M, Hasegawa S, Sakai Y. Department of Surgery, Kyoto University Graduate School of Medicine, 54 Shogoin- Kawara-cho, Sakyo-ku, Kyoto, 606-8507, Japan Link to Article
2013 Dramatic and delayed response to Doxorubicin-dacarbazine chemotherapy of a giant desmoid tumor: case report and literature review. Monneur A, Chetaille B, Perrot D, Guiramand J, Bertucci F. Department of Medical Oncology, Institut Paoli-Calmettes, Marseille, France. Link to Article
2013 A Case of Desmoid-Type Fibromatosis Arising after Thoracotomy for Lung Cancer with a Review of the English and Japanese Literature. Mori T, Yamada T, Ohba Y, Yoshimoto K, Ikeda K, Shiraishi K, Suzuki M. Department of Thoracic Surgery, Graduate School of Medical Sciences, Kumamoto University. Link to Article
2013 Abdominal wall desmoid tumours. Verfaillie G, Vanhoeij M, Hoorens A, Lamote J. Department of Oncologic and Thoracic Surgery, UZ Brussel, Brussels. Link to Article
2013 Intraabdominal desmoid tumors in familial adenomatous polyposis. Galletto P, Leoz ML, Castells A, Balaguer F. Servicio de Gastroenterología, Hospital Clínic, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), IDIBAPS, Universidad de Barcelona, Barcelona, España. Link to Article
2013 Erratum to Desmoid Fibromatosis in Pediatric Patients: Management Based on a Retrospective Analysis of 59 Patients and a Review of the Literature"" Oudot C, Orbach D, Minard-Colin V, Michon J, Mary P, Glorion C, Helfre S, Habrand JL, Oberlin O. Pediatric Oncology Department, Hôpital de la Mère et de l'Enfant, 87042 Limoges, France. Link to Article
2013 A Prognostic Nomogram for Prediction of Recurrence in Desmoid Fibromatosis. Crago AM, Denton B, Salas S, Dufresne A, Mezhir JJ, Hameed M, Gonen M, Singer S, Brennan MF. Departments of *Surgery †Biostatistics and Epidemiology, Memorial Sloan-Kettering Cancer Center, New York, NY Link to Article
2013 Low-dose dacarbazine-doxorubicin therapy against intra-abdominal desmoid tumors. Yamamoto H, Oshiro R, Nishimura J, Uemura M, Haraguchi N, Hata T, Takemasa I, Mizushima T, Sekimoto M, Doki Y, Mori M. Department of Surgery, Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan Link to Article
2013 Desmoid tumor of posterior cruciate ligament of the knee: a case report. Ling W, Kedong S, Hong W, Weiguo Z, Decheng L. Department of Oncology, First Affiliated Hospital of Dalian Medical University, Dalian, People's Republic of China. Link to Article
2013 Abdominal Wall Desmoid during Pregnancy: Diagnostic Challenges. Awwad J, Hammoud N, Farra C, Fares F, Abi Saad G, Ghazeeri G. Department of Obstetrics and Gynecology, American University of Beirut Medical Center, P.O. Box 113-6044, Beirut, Lebano Link to Article
2013 Abdominal Wall Desmoid during Pregnancy: Diagnostic Challenges. Awwad J, Hammoud N, Farra C, Fares F, Abi Saad G, Ghazeeri G. Department of Obstetrics and Gynecology, American University of Beirut Medical Center, P.O. Box 113-6044, Beirut, Lebanon. Link to Article
2013 Abdominal Wall Desmoid during Pregnancy: Diagnostic Challenges. Awwad J, Hammoud N, Farra C, Fares F, Abi Saad G, Ghazeeri G. Department of Obstetrics and Gynecology, American University of Beirut Medical Center, P.O. Box 113-6044, Beirut, Lebanon. Link to Article
2013 Trismus release in a pediatric patient using a parascapular free flap reconstruction following desmoid tumor resection. Crawley MB, Anand SM, Clain JB, Scherl S, Buchbinder D, Urken ML. University of Buffalo School of Medicine, Buffalo, New York, U.S.A. Link to Article
2013 Gardner's syndrome: a clinical and genetic study of a family Cristofaro MG, Giudice A, Amantea M, Riccelli U, Giudice M. Department of Oral and Maxillofacial Surgery, University Magna Graecia, Catanzaro, Italy. Link to Article
2013 Fibroblastic tumors of intermediate malignancy in childhood. Ferrari A, Alaggio R, Meazza C, Chiaravalli S, de Pava MV, Casanova M, Cavaliere E, Bisogno G. Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. Link to Article
2013 Breast fibromatosis mimicking breast carcinoma. Ha KY, Deleon P, Hamilton R. Department of Radiology, Baylor University Medical Center at Dallas. Link to Article
2013 Desmoid fibromatosis in children and adolescents: a conservative approach to management. Honeyman JN, Theilen TM, Knowles MA, McGlynn MM, Hameed M, Meyers P, Crago AM, La Quaglia MP. Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. Link to Article
2013 Desmoid tumor of posterior cruciate ligament of the knee: a case report. Ling W, Kedong S, Hong W, Weiguo Z, Decheng L. Department of Oncology, First Affiliated Hospital of Dalian Medical University, Dalian, People’s Republic of China Link to Article
2013 Neuromuscular choristoma: characteristic magnetic resonance imaging findings and association with post-biopsy fibromatosis. Niederhauser BD, Spinner RJ, Jentoft ME, Everist BM, Matsumoto JM, Amrami KK. Mayo E-2, Department of Radiology, Mayo Clinic, 200 1st St. SW, Rochester, MN, 55905, USA, niederhauser.blake@mayo.edu. Link to Article
2013 A case of a huge recurrent mesenteric desmoid tumor. Ohashi H, Takeo S, Okamoto F, Okazaki Y, Miura O. Department of Surgery, Hofu Gastrointestinal Hospital. Link to Article
2013 Desmoid-type fibromatosis in the head and neck: CT and MR imaging characteristics. Rhim JH, Kim JH, Moon KC, Park SW, Sohn CH, Choi SH, Yun TJ, Chang KH. Department of Radiology, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul, 110-744, South Korea. Link to Article
2013 Desmoid tumour biology in patients with familial adenomatous polyposis coli. Schiessling S, Kihm M, Ganschow P, Kadmon G, Büchler MW, Kadmon M. Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany. Link to Article
2013 The Association Between Home Parenteral Nutrition and Patients With FAP-Associated Intra-abdominal Desmoids: A Retrospective Study. Shatnawei A, Habib M, Hamilton C, Steiger E, Kirby DF, Speerhas R, Quintini C. Department of Gastroenterology and Hepatology, Digestive Disease Institute. Link to Article
2013 Familial adenomatous polyposis: not all masses are desmoids. Sloane J, Ranchod P, Williams G, Clark SK. The Polyposis Registry, St Mark's Hospital, Middlesex, Harrow, HA1 3UI, UK Link to Article
2013 Fibromatosis Arising in Association with Neuromuscular Hematoma of the Mandible. Taher LY, Saleem M, Velagapudi S, Dababo A. Department of Pathology, Taibah University, Al-Madina, Saudi Arabia Link to Article

 

 

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